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Decrease in Shiga toxin expression using a minimal inhibitory concentration of rifampicin followed by bactericidal gentamicin treatment enhances survival of <it>Escherichia coli </it>O157:H7-infected BALB/c mice

<p>Abstract</p> <p>Background</p> <p>Treatment of <it>Escherichia coli </it>O157:H7 infections with antimicrobial agents is controversial due to an association with potentially fatal sequelae. The production of Shiga toxins is believed to be central to the pathogenesis of this organism. Therefore, d...

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Principais autores: Abdelnoor Alexander M, Sabra Ahmad, Kazzi Natalie, Rahal Elias A, Matar Ghassan M
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2011-09-01
Serier:Annals of Clinical Microbiology and Antimicrobials
Fag:
<it>Escherichia coli </it>O157:H7
rifampicin
gentamicin
Shiga toxins
Online adgang:http://www.ann-clinmicrob.com/content/10/1/34
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