Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

Abstract Modeling adaptive immune responses in induced pluripotent stem cell (iPSC)‐derived liver systems remains a critical barrier for studying immune‐mediated hepatic diseases, including idiosyncratic drug‐induced liver injury (iDILI). Conventional hepatotoxicity models lack the components requir...

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Autors principals:	Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A. Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-11-01
Col·lecció:	Advanced Science
Matèries:	CD8⁺ T cells HLA‐B*57:01 immune‐mediated toxicity liver organoids organoid‐immune co‐culture platforms
Accés en línia:	https://doi.org/10.1002/advs.202508584
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