Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

Abstract Active vitamin D form 1α,25-dihydroxtvitamin D3 (1,25(OH)2D3) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR). Mutated VDR often causes hereditary vitamin D-dependent rickets (VDDR) type II, and pati...

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Detalhes bibliográficos

Principais autores:	Miyu Nishikawa, Naruhiro Murose, Hiroki Mano, Kaori Yasuda, Yasuhiro Isogai, Atsushi Kittaka, Masashi Takano, Shinichi Ikushiro, Toshiyuki Sakaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-07-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-022-16819-7
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