Myoglobin expression improves T-cell metabolism and antitumor effector function

Background The tumor microenvironment is frequently hypoxic and characterized by a scarcity of nutritional resources including a shortage of glucose. As effector T cells have high energy demands, tumor metabolism can contribute to T-cell dysfunction and exhaustion.Methods In this study, we determine...

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Autori principali:	Haifeng C Xu, Diran Herebian, Ertan Mayatepek, Dirk Brenner, Aleksandra A Pandyra, Philipp A Lang, Sascha Dietrich, Julia Werner, Georgios Theodorakis, Ichiro Katahira, Mitrajit Ghosh, Michal Gorzkiewicz, Luisa de Sousa Santos, Ann Kathrin Bergmann, Max Anstötz, Anne Busch, Carsten Berndt
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMJ Publishing Group 2025-06-01
Serie:	Journal for ImmunoTherapy of Cancer
Accesso online:	https://jitc.bmj.com/content/13/6/e011503.full
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Myoglobin expression improves T-cell metabolism and antitumor effector function

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