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Jietacin Derivative Inhibits TNF-α-Mediated Inflammatory Cytokines Production via Suppression of the NF-κB Pathway in Synovial Cells

Synovial inflammation plays a central role in joint destruction and pain in osteoarthritis (OA). The NF-κB pathway plays an important role in the inflammatory process and is activated in OA. A previous study reported that a jietacin derivative (JD), (<i>Z</i>)-2-(8-oxodec-9-yn-1-yl)-1-vinyldiazene 1...

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Autori principali: Kyoko Muneshige, Yuki Inahashi, Makoto Itakura, Masato Iwatsuki, Tomoyasu Hirose, Gen Inoue, Masashi Takaso, Toshiaki Sunazuka, Yoshihisa Ohashi, Etsuro Ohta, Kentaro Uchida
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-12-01
Serie:Pharmaceuticals
Soggetti:
jietacin derivative
NF-κB
osteoarthritis
synovial inflammation
Accesso online:https://www.mdpi.com/1424-8247/16/1/5
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