Polygenic risk modulates myocardial repolarization and T-wave geometry in congenital long-QT syndrome type 1: evidence from digital ECG phenotyping

IntroductionCongenital long-QT syndrome type 1 (LQT1), one of the major LQTS subtypes caused by pathogenic variants in the KCNQ1 gene, exhibits marked phenotypic variability, including incomplete penetrance and differences in myocardial repolarization. This variability suggests that additional genet...

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Detalhes bibliográficos

Principais autores:	Elinor Tzvi-Minker, Sven Dittmann, Christian Krijger Juárez, Andreas Keck, Eric Schulze-Bahr
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Cardiovascular Medicine
Assuntos:	electrocardiogram (ECG) long-QT syndrome (LQTS) polygenic risk score QT interval T-wave morphology
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcvm.2026.1736409/full
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