Integrated transcriptomic profiling of programmed cell death patterns unveils macrophage-hepatocyte crosstalk via THBS1-CD47 axis in hepatic ischemia-reperfusion injury

BackgroundHepatic ischemia-reperfusion injury (HIRI) is clinically linked to post-transplant complications, yet the pathogenic role of programmed cell death (PCD) patterns in this process remains poorly delineated. This study aimed to investigate the diversity of programmed cell death (PCD) patterns...

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Principais autores:	Manling Xie, Changquan Zhang, Lirong Zhu, Yongfeng Pei, Chunyan Liang, Lixin Fu, Haibin Li, Liugen Lan, Ning Wen, Jihua Wu, Xuyong Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Immunology
Assuntos:	hepatic ischemia-reperfusion injury macrophage-hepatocyte crosstalk PI3K-AKT- NF-κB signaling programmed cell death THBS1-CD47 axis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1769849/full
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