Comparison of the pharmacokinetic and pharmacodynamic properties of two recombinant granulocyte colony-stimulating factor formulations after single subcutaneous administration to healthy volunteers

Background and objective: The aim of this randomized, single dose, two-period crossover study with two weeks wash-out period was the demonstration of bioequivalence of two recombinant human granulocyte colony-stimulating factor (rG-CSF) formulations after subcutaneous administration of 300 μg compar...

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Detalhes bibliográficos

Principais autores:	Audrius Sveikata, Gintautas Gumbrevičius, Kastytis Šeštakauskas, Rima Kregždytė, Vytautas Janulionis, Vidmantas Fokas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2014-01-01
coleção:	Medicina
Assuntos:	Human granulocyte colony-stimulating factor Biosimilarity Pharmacokinetics Pharmacodynamics Safety
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1010660X14000500
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