Tissue plasminogen activator in brain tissues infected with transmissible spongiform encephalopathies
Prion propagation involves conversion of host PrPC to a disease-related isoform, PrPSc, which accumulates during disease and is the principal component of the transmissible agent. Proteolysis seems to play an important role in PrP metabolism. Plasminogen, a serine protease precursor, has been shown...
Gardado en:
| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2005-11-01
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| Series: | Neurobiology of Disease |
| Assuntos: | |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S0969996105001269 |
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