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A Single Amino Acid Substitution in Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 2 Significantly Impairs Its Infectivity in Macrophages

Porcine reproductive and respiratory syndrome virus (PRRSV) has a restricted tropism for macrophages and CD163 is a key receptor for infection. In this study, the PRRSV strain NCV1 was passaged on MARC-145 cells for 95 passages, and two plaque-clones (C1 and C2) were randomly selected for further an...

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Bibliografiske detaljer
Principais autores: Jayeshbhai Chaudhari, Raquel Arruda Leme, Kassandra Durazo-Martinez, Sarah Sillman, Aspen M. Workman, Hiep L. X. Vu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-12-01
Serier:Viruses
Fag:
Online adgang:https://www.mdpi.com/1999-4915/14/12/2822
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