The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance

Abstract Background Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that genetic or pharmacological inhibition of the NHEJ pathway could rescue the...

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Auteurs principaux:	Yan Nie, Yibo Li, Xiaoli Li, Andrew F. Wilson, Qishen Pang
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2019-03-01
Collection:	Stem Cell Research & Therapy
Sujets:	Fanconi anemia (FA) Hematopoietic stem cells (HSCs) Homologous recombination (HR) Non-homologous end joining (NHEJ)
Accès en ligne:	http://link.springer.com/article/10.1186/s13287-019-1206-0
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