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A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

In pursuit of therapeutics for human polyomaviruses, we identified a peptide derived from the BK polyomavirus (BKV) minor structural proteins VP2/3 that is a potent inhibitor of BKV infection with no observable cellular toxicity. The thirteen-residue peptide binds to major structural protein VP1 wit...

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Principais autores: Joshua R Kane, Susan Fong, Jacob Shaul, Alexandra Frommlet, Andreas O Frank, Mark Knapp, Dirksen E Bussiere, Peter Kim, Elizabeth Ornelas, Carlos Cuellar, Anastasia Hyrina, Johanna R Abend, Charles A Wartchow
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2020-01-01
Serier:eLife
Fag:
BK polyomavirus
JC polyomavirus
peptide
antiviral
Online adgang:https://elifesciences.org/articles/50722
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