Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects

Lysine deacetylases (KDACs or HDACs) are metal‐dependent enzymes that regulate lysine acetylation, a post‐translational modification that is present on thousands of human proteins, essential for many cellular processes, and often misregulated in diseases. The selective inhibition of KDACs would allo...

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Bibliografski detalji

Glavni autori:	Kiara E. Bornes, Marcus A. Moody, Thomas M. Huckaba, Megan C. Benz, Emily C. McConnell, Maryam Foroozesh, Van H. Barnes, Bridgette M. Collins‐Burow, Matthew E. Burow, Terry J. Watt, Tasha B. Toro
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-01-01
Serija:	FEBS Open Bio
Teme:	HDAC6 HDAC8 HDACi immunofluorescence RNA‐seq
Online pristup:	https://doi.org/10.1002/2211-5463.13896
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