Serious issues with cryo-EM structures of human prothrombinase
Thrombin is generated from prothrombin through sequential cleavage at two sites by the enzyme complex prothrombinase, composed of a serine protease, factor (f) Xa and a cofactor, fVa, on phospholipid membranes. In a recent paper published in Blood, Ruben et al. (Ruben et al. 2022 Blood 139, 3463–347...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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The Royal Society
2025-01-01
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| Schriftenreihe: | Open Biology |
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| Online-Zugang: | https://royalsocietypublishing.org/doi/10.1098/rsob.240193 |
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