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Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1

<p>Abstract</p> <p>Background</p> <p>The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating. However, in cancer cells, by the expression of telomerase which elong...

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Principais autores: Yoshitake Kazutoshi, Aoyagi Hideyuki, Fujiwara Haruhiko
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2010-04-01
Series:Mobile DNA
Acceso en liña:http://www.mobilednajournal.com/content/1/1/13
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