Variant reclassification in cancer susceptibility genes and an updated variant spectrum of Turkish breast and colorectal cancer patients

Abstract Multigene panel testing (MGPT) is a powerful tool for identifying pathogenic variants (PVs) underlying hereditary cancers. However, the clinical interpretation of variants of uncertain significance (VUS) remains a major challenge, particularly in populations underrepresented in population g...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Nisan Denizce Can, Izzet Mehmet Akcay, Elifnaz Celik, Ceren Ciftci, Busra Unal, Nihat Bugra Agaoglu, Hamdi Levent Doganay, Gizem Dinler Doganay
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-02-01
Schriftenreihe:	Human Genomics
Schlagworte:	Breast cancer Colorectal cancer Hereditary cancer predisposition Multigene panel testing Variant reclassification
Online-Zugang:	https://doi.org/10.1186/s40246-026-00915-0
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