Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

Introduction: Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of the Raphe Pallidus, a reversible brain Tau hyperphosphorylation...

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Auteurs principaux:	Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-03-01
Collection:	Frontiers in Physiology
Sujets:	deep hypothermia microtubules melatonin glycogen synthase kinase 3β hippocampus parietal cortex
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1129278/full
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