Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid

Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene editing, a principal problem in implementing this new process is deliv...

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Principais autores:	Ami Jo, Veronica M. Ringel-Scaia, Dylan K. McDaniel, Cassidy A. Thomas, Rui Zhang, Judy S. Riffle, Irving C. Allen, Richey M. Davis
格式:	Artigo
語言:	Inglês
出版:	BMC 2020-01-01
叢編:	Journal of Nanobiotechnology
主題:	Nanoprecipitation Transfection CRISPR–Cas9 PLGA nanoparticles
在線閱讀:	https://doi.org/10.1186/s12951-019-0564-1
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