A real-world study of adverse event profiles associated with the four key components of antibody–drug conjugates based on the FAERS database

BackgroundAntibody–drug conjugates (ADCs) exhibit structurally driven and highly heterogeneous toxicities, yet most pharmacovigilance studies remain drug-centered and lack systematic component-level evaluation. This study provides a comprehensive real-world safety assessment of FDA-approved ADCs usi...

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Bibliografische Detailangaben

Hauptverfasser:	Shuning Zhang, Chun Ye, Jiaxuan Zhu, Miao Wang, Yanyan Xu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-02-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	antibody–drug conjugates component type-specific toxicity drug-to-antibody ratio food and drug administration adverse event reporting system hepatobiliary toxicity ocular toxicity
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1702195/full
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