Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations

Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plas...

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Autori principali:	Cristina Pardo-Camacho, John-Peter Ganda Mall, Cristina Martínez, Marc Pigrau, Elba Expósito, Mercé Albert-Bayo, Elisa Melón-Ardanaz, Adoración Nieto, Bruno Rodiño-Janeiro, Marina Fortea, Danila Guagnozzi, Amanda Rodriguez-Urrutia, Inés de Torres, Ignacio Santos-Briones, Fernando Azpiroz, Beatriz Lobo, Carmen Alonso-Cotoner, Javier Santos, Ana M. González-Castro, Maria Vicario
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-06-01
Serie:	Cells
Soggetti:	intestinal plasma cells intestinal glycocalyx IBS-D mucosal ultrastructure intestinal barrier dysfunction mucosal nerve fibres
Accesso online:	https://www.mdpi.com/2073-4409/11/13/2046
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