USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes

IntroductionUbiquitin-specific proteases (USPs), a large subset of more than 50 deubiquitinase proteins, have recently emerged as promising targets in cancer. However, their role in immune cell regulation, particularly in T cell activation, differentiation, and effector functions, remains largely un...

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Autores principales:	Gwenaëlle Le Menn, Keela Pikkarainen, Daniela Mennerich, Dominika Miroszewska, Thomas Kietzmann, Zhi Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2024-07-01
Colección:	Frontiers in Immunology
Materias:	DSS-induced colitis T cell USP28 inflammation IL22 Stat5
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1401949/full
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