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Gatm ablation disrupts spermatogenesis by impairing ribosome biogenesis and coupling defective steroid biosynthesis to immunoglobulin silencing

BackgroundGlycine amidinotransferase (GATM) catalyzes the rate-limiting step in creatine biosynthesis, a pathway essential for cellular energy buffering in tissues with high metabolic demands. While its roles in muscle and brain are well established, the function of GATM in testicular development an...

Täydet tiedot

Tallennettuna:
Päätekijät: Shun Li, Lixiang Chen, Mengmin Zhu, Lin Yang, Hanqing Wu, Xiaohui Zhou
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2026-03-01
Sarja:Frontiers in Cell and Developmental Biology
Aiheet:
cacospermia
creatine metabolism
GATM
immunoglobulin silencing
male infertility
ribosome biogenesis
Linkit:https://www.frontiersin.org/articles/10.3389/fcell.2026.1786659/full
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