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Elucidation of the influence of the CaV2.2 calcium channel on ALS disease progression in the SOD1*G93A mouse model

Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal neurodegenerative disease affecting upper and lower motor neurons in the central nervous system. Drugs like riluzole, edaravone, and tofersen treat disease symptoms or are designed for a specific pathological mutation (e.g., SOD1), but they...

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Principais autores: Katharina Wintz, Paul Luca Lechtape, Jannes Klenzendorf, Sarah Schemmert, Andrew J. Dingley, Antje Willuweit, Janine Kutzsche
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-06-01
coleção:Neurobiology of Disease
Assuntos:
Amyotrophic lateral sclerosis
Behavior
Motor coordination
CaV2.2
SOD1*G93A
Double-transgenic mice
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996126001415
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