RM2 and DB15 analogues bearing [177Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Abstract Background Bombesin analogues are gaining popularity as GRPR-targeting theranostic agents aiming to provide molecular tools for a patient-tailored management. We previously reported on two series of DOTAGA-bearing GRPR-antagonists, based on either [NMe-Gly11]RM26 (DOTAGA-X-DPhe-Gln-Trp-Ala-...

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Auteurs principaux:	Panagiotis Kanellopoulos, Athanasios Bitzios, Ivan Zelepukin, Ekaterina Bezverkhniaia, Theodosia Maina, Berthold A. Nock, Vladimir Tolmachev, Anna Orlova
Format:	Artigo
Langue:	Inglês
Publié:	SpringerOpen 2025-07-01
Collection:	EJNMMI Radiopharmacy and Chemistry
Sujets:	GRPR Bombesin Lu-177 Radiotherapy PRRT Pharmacokinetics
Accès en ligne:	https://doi.org/10.1186/s41181-025-00374-3
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