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Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness

Biomass and cell-specific metabolic rates usually change dynamically over time, making the “feed according to need” strategy difficult to realize in a commercial fed-batch process. We here demonstrate a novel feeding strategy which is designed to hold a particular metabolic state in a fed-batch proc...

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Principais autores: Viktor Konakovsky, Christoph Clemens, Markus Michael Müller, Jan Bechmann, Martina Berger, Stefan Schlatter, Christoph Herwig
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2016-01-01
Series:Bioengineering
Assuntos:
CHO cell culture
scale-down
fed batch
automation
Lactic acid control
pH
metabolic control
MVDA
uncertainty
online analyzer
Acceso en liña:http://www.mdpi.com/2306-5354/3/1/5
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