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Early Higher Plasma Regorafenib Concentration Predicts Shorter PFS in Japanese Patients With mCRC

ABSTRACT The pharmacokinetics of regorafenib and its active metabolites, M2 and M5, vary widely among individual patients. However, the relationship between these plasma concentrations and therapeutic efficacy remains unclear. Patients with metastatic colorectal cancer (mCRC) receiving regorafenib a...

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Principais autores: Kazuo Kobayashi, Takeru Wakatsuki, Erika Sugiyama, Eiji. Shinozaki, Masataka Tajima, Mariko Ogura, Keisho Chin, Akira Ooki, Hiroki Osumi, Shota Fukuoka, Shohei Udagawa, Keitaro Shimozaki, Takeshi Aoyama, Yasuhiro Nakano, Kazuyoshi Kawakami, Wataru Suzuki, Takashi Yokokawa, Hitoshi Sato, Masakazu Yamaguchi, Kensei Yamaguchi
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-11-01
Serier:Clinical and Translational Science
Fag:
neutrophil to lymphocyte ratio
pharmacokinetics
polymorphisms
progression‐free survival
regorafenib
Online adgang:https://doi.org/10.1111/cts.70386
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