Harnessing the thermotolerant methylotroph Bacillus methanolicus for methanol-based synthetic L-proline production

Abstract Background Bacillus methanolicus MGA3 is a thermotolerant methylotroph that utilizes methanol, a renewable C₁ substrate, as its sole carbon and energy source. The strain naturally overproduces and secretes L-glutamate, making it a promising platform for engineering pathways toward L-glutama...

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Principais autores:	Christine Frank, David Virant, Gregor Kosec, Tamara Hoffmann, Oskar Zelder, Max F. Felle, Erhard Bremer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Microbial Cell Factories
Assuntos:	Bacilli Amino acids Methanol Synthetic microbiology Cell factory Excretion
Acesso em linha:	https://doi.org/10.1186/s12934-026-03032-8
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