Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Abstract Background Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 diabetes mellitus. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been developed to ameliorate insulin resistance, the limitations and accompanyi...

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Autors principals:	Guang Chen, Xiao-yan Fan, Xiao-peng Zheng, Yue-lei Jin, Ying Liu, Shuang-chun Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2020-09-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	HUC-MSCs Insulin resistant PTEN, crosstalk PI3K/Akt Erk/MAPK Db/db mice
Accés en línia:	http://link.springer.com/article/10.1186/s13287-020-01865-7
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