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Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Background: Aseptic loosening of prosthesis (ALP) is one of the most common long-term complications of knee and hip arthroplasty. Wear particle-induced osteoclastogenesis and subsequent periprosthetic osteolysis account for the morbidity of ALP. Here, we investigate the potential of cimifugin (CIM),...

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Principais autores: Juan Duan, Xuantao Hu, Tao Li, Gen Wu, Pengcheng Dou, Zhengxiao Ouyang
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2021-09-01
סדרה:Frontiers in Pharmacology
נושאים:
osteoclast
NF-κB
p38
MAPK
aseptic prosthetic loosening
periprosthetic osteolysis
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fphar.2021.724256/full
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