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Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling pathway to evade T cell-mediated cytotoxicity

ABSTRACT Human cytomegalovirus (HCMV), a widely prevalent human beta-herpesvirus, establishes lifelong persistence in the host following primary infection. In healthy individuals, the virus is effectively controlled by HCMV-specific T cells and typically exhibits asymptomatic. The T cell immune resp...

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Principais autores: Qin Yuan, Zhaosong Fan, Wenqiang Huang, Xiaoping Huo, Xiaoping Yang, Yanhong Ran, Jun Chen, Hongjian Li
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2024-07-01
Serier:mBio
Fag:
human cytomegalovirus (HCMV)
UL23
T cell cytotoxicity
immune evasion
IFN-γ
PD-L1
Online adgang:https://journals.asm.org/doi/10.1128/mbio.01191-24
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