Effects of extracellular metabolic acidosis and out-of-equilibrium CO2/HCO3− solutions on intracellular pH in cultured rat hippocampal neurons

Metabolic acidosis (MAc)—an extracellular pH (pHo) decrease caused by a [HCO3−]o decrease at constant [CO2]o—usually causes intracellular pH (pHi) to fall. Here we determine the extent to which the pHi decrease depends on the pHo decrease vs the concomitant [HCO3−]o decrease. We use rapid-mixing to...

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Bibliographic Details

Main Authors:	Patrice G. Bouyer, Ahlam I. Salameh, Yuehan Zhou, Tiffany N. Kolba, Walter F. Boron
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2024-10-01
Series:	Frontiers in Physiology
Subjects:	CO2/HCO3− out of equilibrium solutions pH regulation HCO3− sensor pHo sensor acid base neuron
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2024.1434359/full
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