EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

Abstract Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M-HNSCC) is a severe, frequently lethal condition. Oncogene addiction to epidermal growth factor receptor (EGFR) is a hallmark of HNSCC, but the clinical efficacy of EGFR-targeted therapies remains low. Understanding m...

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Auteurs principaux:	Jiefu Zhou, Min He, Qiong Zhao, Enxian Shi, Hairong Wang, Vaidehi Ponkshe, Jiahang Song, Zhengquan Wu, Dongmei Ji, Gisela Kranz, Anna Tscherne, Sabina Schwenk-Zieger, Nilofer Abdul Razak, Julia Hess, Claus Belka, Horst Zitzelsberger, Iordanis Ourailidis, Fabian Stögbauer, Melanie Boxberg, Jan Budczies, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Hongxia Wang, Kristian Unger, Andreas Mock, Olivier Gires
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-03-01
Collection:	Molecular Cancer
Sujets:	Oncogene addiction EGFR R/M-HNSCC Cetuximab EMT Local invasion
Accès en ligne:	https://doi.org/10.1186/s12943-025-02290-1
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