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CYP3A4, CYP3A5, and CYP4F2 Polymorphisms and Bleeding Risk in Ticagrelor-Based Dual Antiplatelet Therapy

<i>Background and Objectives</i>: Ticagrelor reduces ischemic events in acute coronary syndrome (ACS) but increases bleeding risk. Clinical predictors of bleeding are well established; the contribution of cytochrome P450 polymorphisms involved in ticagrelor metabolism remains uncertain, with conflic...

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Principais autores: Sonja Dakić, Zoran Perišić, Svetlana Apostolović, Tomislav Kostić, Goran Koraćević, Tatjana Jevtović, Boris Đinđić, Nikola Stefanović, Danijela Đorđević-Radojković, Bojan Maričić, Dragana Stanojević, Maša Jović, Jelena Perišić, Tamara Filipović
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Medicina
Fag:
ticagrelor
acute coronary syndrome
bleeding
pharmacogenetics
CYP3A4
CYP3A5
Online adgang:https://www.mdpi.com/1648-9144/62/6/1202
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