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Gut microbiota-derived phenylacetylglutamine mitigates neuroinflammation induced by intracerebral hemorrhage in mice

Background: Emerging evidence highlights the pivotal role of gut microbiota and its metabolites in the pathogenesis of brain injury following intracerebral hemorrhage (ICH). Microglia-mediated neuroinflammation stands out as a crucial pathophysiological process post-ICH. However, the effects of gut...

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Main Authors: Weiwei Zhang, Haopu Lin, Xuchao He, Qiuping Gu, Yan Ma, Xiongjie Fu, Linfeng Fan
Format: Artigo
Language:Inglês
Published: Elsevier 2025-08-01
Series:Journal of Stroke and Cerebrovascular Diseases
Subjects:
Intracerebral hemorrhage
Gut-derived metabolites
Phenylacetylglutamine
Microglia
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1052305725001351
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