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Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter

Concentration-response relationships connecting the concentration of ligands to the responses they produce are central to pharmacology in general and form the core of quantitative pharmacology. While typically they can be well-described by hyperbolic functions (sigmoid on commonly used semi-log scal...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Kaituhi matua: Peter Buchwald
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2025-04-01
Rangatū:Frontiers in Pharmacology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fphar.2025.1541872/full
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