Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections

Abstract Background In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective observational study to describe the pharmacokinetic/pharmacodynamic (PK...

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Principais autores:	Gennaro De Pascale, Lucia Lisi, Gabriella Maria Pia Ciotti, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Di Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra, Massimo Antonelli
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-07-01
Series:	Annals of Intensive Care
Assuntos:	Tigecycline High dose Pharmacokinetics Epithelial lining fluid Critically ill patients Severe infections
Acceso en liña:	http://link.springer.com/article/10.1186/s13613-020-00715-2
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