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Rational design of a flavoenzyme for aerobic nicotine catabolism

ABSTRACT Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model. However, when O2 is used as the electron acceptor, no satisfactory performance has been achieved with one of th...

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Autori principali: Haiyang Hu, Zhaoyong Xu, Zhiyao Zhang, Peizhi Song, Frederick Stull, Ping Xu, Hongzhi Tang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2024-10-01
Serie:mBio
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Accesso online:https://journals.asm.org/doi/10.1128/mbio.02050-24
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