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Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration

Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked to cognitive symptoms that precede neuronal loss and neurodegeneration. Neurogranin (Ng) is a somatodendritic protein that has been shown to be reduced in brain tissue but incr...

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Principais autores: Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-02-01
Serier:Neurobiology of Disease
Fag:
Neurogranin
SIMOA
CSF biomarker
Alzheimer's disease
Inducible p25 mice
Synaptic loss
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996119303201
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