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Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondri...

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Principais autores: Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2018-04-01
coleção:eLife
Assuntos:
mitochondria
contact site
mitophagy
Parkinson's disease
ubiquitination
Acesso em linha:https://elifesciences.org/articles/32866
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