The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

Inhibition of the interaction between the scaffolding protein PSD-95 and the NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading to neuronal death. The peptides NR2B9c and N-dimer are inhibitors of this interaction. Delivery of the peptides to the brain...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Emma Lisa Al Humaidan, Sidse Lund Pedersen, Annette Burkhart, Charlotte Laurfelt Munch Rasmussen, Torben Moos, Peter Fuchs, Eduardo Filipe Alves Fernandes, Burak Ozgür, Kristian Strømgaard, Anders Bach, Birger Brodin, Mie Kristensen
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2022-04-01
سلاسل:	Frontiers in Drug Delivery
الموضوعات:	blood-brain barrer cell-penetrating peptide brain drug delivery ischemic stroke tat
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fddev.2022.854703/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!