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Astrocytic mitochondrial transfer: a new horizon for metabolic rescue and precision therapy in ischemic stroke

Abstract Ischemic stroke (IS) remains a leading cause of global mortality and neurological disability, with neuronal mitochondrial dysfunction as a central pathological mechanism. Astrocytes, the metabolic custodians of the central nervous system, exert neuroprotection by transferring functional mit...

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Principais autores: Xin Lan, Chuxin Zhang, Zilin Ren, Jialin Cheng, Congai Chen, Yuxiao Zheng, Jinhua Han, Yang Zhao, Jiaming Li, Fafeng Cheng, Xueqian Wang, Qingguo Wang, Changxiang Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Journal of Translational Medicine
Fag:
Astrocyte
Ischemic stroke
Neuron
Mitochondrial transfer
Neuroprotection
Online adgang:https://doi.org/10.1186/s12967-025-07290-9
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