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Investigating Functional Roles for Positive Feedback and Cellular Heterogeneity in the Type I Interferon Response to Viral Infection

Secretion of type I interferons (IFN) by infected cells mediates protection against many viruses, but prolonged or excessive type I IFN secretion can lead to immune pathology. A proper type I IFN response must therefore maintain a balance between protection and excessive IFN secretion. It has been w...

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Autors principals: Sivan Leviyang, Igor Griva
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2018-09-01
Col·lecció:Viruses
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Accés en línia:http://www.mdpi.com/1999-4915/10/10/517
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