A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneupl...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2014-03-01
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| Series: | PLoS Biology |
| Acceso en liña: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001815&type=printable |
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