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HIF-1α Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus

Metabolic reprogramming of host cells is key to the foundation of a successful viral infection. Hypoxia inducible factors (HIFs) mediate oxygen utilization by regulating cellular metabolism and redox homeostasis. Under normoxic conditions, HIF proteins are synthesized and subsequently degraded follo...

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Principais autores: Dorothea R. Morris, Yue Qu, Anurodh Agrawal, Roberto P. Garofalo, Antonella Casola
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-09-01
Serier:Viruses
Fag:
respiratory syncytial virus
RSV
metabolism
HIF-1α
HIF-2α
Online adgang:https://www.mdpi.com/1999-4915/12/10/1088
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