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Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by massive neuronal loss in the brain. Both cortical glutamatergic neurons and basal forebrain cholinergic neurons (BFCNs) in the AD brain are selectively vulnerable. The degeneration and dysfunction of these...

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Principais autores: Ran Tao, Chunmei Yue, Zhijie Guo, Wenke Guo, Yao Yao, Xianfa Yang, Zhen Shao, Chao Gao, Jianqing Ding, Lu Shen, Shengdi Chen, Naihe Jing
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2024-10-01
Serier:Cell Regeneration
Fag:
Alzheimer’s disease (AD)
iPSC
Cellular model
Basal forebrain cholinergic neuron (BFCN)
Cortical glutamatergic neuron
Online adgang:https://doi.org/10.1186/s13619-024-00204-y
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