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In silico prediction of structural changes in human papillomavirus type 16 (HPV16) E6 oncoprotein and its variants

Abstract Background HPV16 infection is one of the main risk factors involved in the development of cervical cancer, mainly due to the high oncogenic potential of the viral proteins E6 and E7, which are involved in the different processes of malignant transformation. There is a broad spectrum of intr...

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Principais autores: Hugo Alberto Rodríguez-Ruiz, Olga Lilia Garibay-Cerdenares, Berenice Illades-Aguiar, Sarita Montaño, Xiaowei Jiang, Marco Antonio Leyva-Vázquez
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-08-01
Serier:BMC Molecular and Cell Biology
Fag:
HPV16
E6 oncoprotein variants
3D structure
Molecular modeling
Protein disorder
Molecular dynamics simulations
Online adgang:http://link.springer.com/article/10.1186/s12860-019-0217-0
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