Quantitative Structure-Activity Relationship, Structure-based Design, and ADMET studies of pyrimethamine and cycloguanil analogs inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS).
ABSTRACT: The increasing resistance of the malarial parasite to readily available drugs ensures a continuous battle against endemic diseases. Hence, the search for antimalarial drugs with enhanced activity against the P. falciparum strain becomes an endless one. The objective of this study is to use...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2022-12-01
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| Col·lecció: | Chemical Physics Impact |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2667022422000706 |
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