Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Summary: Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial Pyruvate Carrier (MPC) in mice attenuates NAFLD. Thus, we considered whether liver MPC disruption also prevents HCC. Here, we use the N...

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Hauptverfasser:	Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2019-09-01
Schriftenreihe:	Cell Reports
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124719310149
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