A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex

Abstract Background Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases (SFKs) and produces inositol 1,4,5-triphosphate (InsP3) from phosphatidylinositol 4,5-bisphosphate (PIP2). Inositol polyphos...

Полное описание

Библиографические подробности

Главные авторы:	Sehoon Hong, Kyurae Kim, Young-Ri Shim, Jiyeon Park, Sung Eun Choi, Hyungyu Min, Seulgi Lee, Ji-Joon Song, Suk-Jo Kang, Won-Il Jeong, Rho Hyun Seong, Seyun Kim
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-10-01
Серии:	Cell Communication and Signaling
Предметы:	Inositol polyphosphate multikinase Phospholipase C gamma 1 Sam68 T cell receptor Hepatitis
Online-ссылка:	https://doi.org/10.1186/s12964-024-01907-0
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!