Viscoelastic properties of sodium hyaluronate and their mathematical optimization in intra-articular injections: a predictive model for enhancing clinical efficacy

ObjectiveTo develop and validate a biomechanical and mathematical model capable of predicting the clinical efficacy of intra-articular sodium hyaluronate injections (HA) in osteoarthritis (OA), by aligning viscoelastic properties of HA formulations with joint-specific mechanical demands and patient...

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Detalhes bibliográficos

Principais autores:	Horacio Rivarola, Stefano Guerrasio, Luciano Trinchese, Francisco Endara Urresta, Bautista Rivarola
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Bioengineering and Biotechnology
Assuntos:	biomechanics finite element modeling hyaluronic acid osteoarthritis viscoelasticity viscosupplementation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1742722/full
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